Acetic Acid → 2-Acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one

HRID 1747774ノート

反応式

HRID 1747774 の反応式
[C:1]1([C:7](=[O:17])[CH2:8][C:9](=[O:16])[C:10](=[O:15])[CH2:11][C:12](=[O:14])[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1.C(O)(=O)C>O>[C:12]([C:11]1[O:17][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:8][C:9](=[O:16])[C:10]=1[OH:15])(=[O:14])[CH3:13]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 12217721Iodo benzene diacetateHCID 132009181-Phenylheptane-1,3,4,6-tetrone

生成物 1

HCID 132009232-Acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one収率 14%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1-phenylheptane-1,3,4,6-tetrone (2.3 g), iodobenzene diacetate (6.7 g) and acetic acid (80 mL) was stirred at room temperature for 16 hr, the reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.32 g).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-00344df25fe243fab4fc1cd6298b2e0f
出典データセット
uspto-grants-2015_10
特許番号
US09150588B2

反応ノート

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