Dimethylformamide → HCID 89586183、化合物

HRID 1747782ノート

反応式

HRID 1747782 の反応式
[C:1]([C:4]1[O:5][C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][C:8](=[O:11])[C:9]=1[OH:10])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:24](Br)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.CN(C=O)C>O>[C:1]([C:4]1[O:5][C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][C:8](=[O:11])[C:9]=1[O:10][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 132009232-Acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one

生成物 1

HCID 89586183HCID 89586183、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one (0.53 g), potassium carbonate (0.40 g), benzyl bromide (0.27 mL) and DMF (10 mL) was stirred at room temperature for 2 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.18 g).

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-3bcc3a1ecbb14c5283116a1dc7888b5e
出典データセット
uspto-grants-2015_10
特許番号
US09150588B2

反応ノート

読み込み中…