Hydrogen chloride-ethyl acetate → 1-(2-Aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride
反応式
[ClH:1].CCOC(C)=O.[OH:8][C:9]1([C:21]2[C:22]([NH:27]C(=O)OC(C)(C)C)=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1>>[ClH:1].[NH2:27][C:22]1[C:21]([C:9]2([OH:8])[CH2:14][CH2:13][CH:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:11][CH2:10]2)=[CH:26][CH:25]=[CH:24][N:23]=1参加物
3
実験手順
4N HCl-EtOAc (5 mL) was added to tert-butyl [3-(1-hydroxy-4-phenylcyclohexyl)pyridin-2-yl]carbamate (450 mg) and the mixture was stirred at room temperature overnight. The resulted precipitates were collected and dried in vacuo to give 1-(2-aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride.
後処理
- customThe resulted precipitates
- customwere collected
- customdried in vacuo