3-Cyclopropyl-3-Oxopropionic Acid Methyl Ester → 5-Cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazole-4-carboxylic acid

HRID 1748167ノート

反応式

HRID 1748167 の反応式
[OH:1][N:2]=[C:3](Cl)[CH:4]1[CH2:9][CH2:8][C:7]([CH3:11])([CH3:10])[CH2:6][CH2:5]1.[CH:13]1([C:16](=O)[CH2:17][C:18]([O:20]C)=[O:19])[CH2:15][CH2:14]1>>[CH:13]1([C:16]2[O:1][N:2]=[C:3]([CH:4]3[CH2:9][CH2:8][C:7]([CH3:11])([CH3:10])[CH2:6][CH2:5]3)[C:17]=2[C:18]([OH:20])=[O:19])[CH2:15][CH2:14]1

参加物

3

反応物 2

HCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl EsterHCID 86704402N-Hydroxy-4,4-dimethylcyclohexanecarbimidoyl chloride

生成物 1

HCID 679838155-Cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazole-4-carboxylic acid

実験手順

5-cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazole-4-carboxylic acid (I-9E) Was prepared by reaction of N-hydroxy-4,4-dimethylcyclohexanecarbimidoyl chloride and methyl 3-cyclopropyl-3-oxopropanoate following the same protocol as described for I-6E. MS m/z 264.1 (M+1).

出典と根拠

ORDレコード
ord-9af996ffa3ee428aaffeb590dd090040
出典データセット
uspto-grants-2015_10
特許番号
US09150568B2

反応ノート

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