Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde → 1-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

HRID 1748486ノート

反応式

HRID 1748486 の反応式
CO[CH:3]1[CH:7]([CH:8]=[O:9])[CH2:6][CH:5](OC)O1.Cl.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>O>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH:5]=[CH:6][C:7]([CH:8]=[O:9])=[CH:3]2)=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 567310Tetrahydro-2,5-dimethoxyfuran-3-carbaldehydeHCID 27349564-Anisidine hydrochloride

生成物 1

HCID 105599931-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

2,5-Dimethoxytetrahydrofuran-3-carbaldehyde (7.31 g) and p-anisidine hydrochloride (7.28 g) were added to water (100 ml) and stirred at 60° C. for three hours. The precipitated yellow solid were filtered at the same temperature, washed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml) to give 1-(4-methoxyphenyl)pyrrole-3-carb aldehyde.

後処理

  1. filtrationThe precipitated yellow solid were filtered at the same temperature
  2. washwashed with water (50 ml), saturated aqueous solution of sodium bicarbonate (50 ml), and further water (50 ml)

出典と根拠

ORDレコード
ord-88551588a76e48aaa70c5b1b9d121d31
出典データセット
uspto-grants-2015_10
特許番号
US09150555B2

反応ノート

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