Potassium Carbonate → 5-bromo-2-(tetrahydro-2H-pyran-4-yl)pyridine
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2(C#N)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
4-(5-Bromopyridin-2-yl)tetrahydro-2H-pyran-4-carbonitrile (2 g) described in Reference Example 87 in concentrated hydrochloric acid (10 ml) was stirred at 100° C. for 3 days. After completion of the reaction, a saturated aqueous solution of potassium carbonate was added to alkalify the mixture, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated to give the titled compound (1.05 g) as a white solid.
後処理
- customAfter completion of the reaction
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-bf40929f083e4d4c98976e74897962a2
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150555B2
反応ノート
読み込み中…