1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid → 5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

HRID 1748598ノート

反応式

HRID 1748598 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=[O:15])[CH:10]=[N:9]2)=[N:6][CH:7]=1>CN(C)C=O.[C].[Pd]>[CH3:13][C:12]1[N:8]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][N:6]=2)[N:9]=[CH:10][C:11]=1[C:14]([OH:16])=[O:15]

参加物

4

反応物 1

HCID 653475861-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid

生成物 1

HCID 167776245-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid収率 106.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid (30 mg) described in Reference Example 24 in N,N-dimethylformamide (1 ml) was added 10% palladium carbon (containing about 50% water) (10 mg) at room temperature, and stirred at the same temperature for 30 minutes under hydrogen atmosphere. After completion of the reaction, the reaction solution was filtered through Celite, then the solvent was evaporated in vacuo, azeotropically concentrated together with toluene to give the titled compound (23 mg) as a white solid.

後処理

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered through Celite
  3. customthe solvent was evaporated in vacuo
  4. concentrationazeotropically concentrated together with toluene

出典と根拠

ORDレコード
ord-3282666ea7814e558169ab2525ffbf40
出典データセット
uspto-grants-2015_10
特許番号
US09150555B2

反応ノート

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