ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Dichloromethane → N-{6-[1-(Dimethylsulfamoyl)piperidin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

HRID 1748686
ノート
印刷プレビュー

反応式

HRID 1748686 の反応式
C(N(CC)CC)C.[CH3:8][N:9]([CH3:14])[S:10](Cl)(=[O:12])=[O:11].[CH3:15][C:16]1[N:20]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=2)[N:19]=[CH:18][C:17]=1[C:31]([NH:33][C:34]1[CH:35]=[N:36][C:37]([CH:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)=[C:38]([CH3:40])[CH:39]=1)=[O:32].ClCCl>O>[CH3:8][N:9]([CH3:14])[S:10]([N:44]1[CH2:43][CH2:42][CH:41]([C:37]2[N:36]=[CH:35][C:34]([NH:33][C:31]([C:17]3[CH:18]=[N:19][N:20]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=4)[C:16]=3[CH3:15])=[O:32])=[CH:39][C:38]=2[CH3:40])[CH2:46][CH2:45]1)(=[O:12])=[O:11]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 8471Triethylamine2 回HCID 83372Dimethylsulphamoyl chloride2 回HCID 866925445-Methyl-N-[5-methyl-6-(piperidin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

生成物 1

HCID 86692636N-{6-[1-(Dimethylsulfamoyl)piperidin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Triethylamine (73 μl) and dimethylsulfamoyl chloride (56 μl) were added to a mixture of 5-methyl-N-[5-methyl-6-(piperidin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (222 mg) described in Reference Example 171 and dichloromethane (10 ml), stirred at room temperature for 6.5 hours, triethylamine (146 μl) and dimethylsulfamoyl chloride (56 μl) were added and stirred at room temperature for 7.5 hours. Water was added to the reaction solution, extracted with chloroform, the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The precipitated solid was washed with ethyl acetate and ethanol to give the titled compound (122 mg) as a white solid.

後処理

  1. stirringstirred at room temperature for 7.5 hours
  2. extractionextracted with chloroform
  3. washthe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo
  6. washThe precipitated solid was washed with ethyl acetate and ethanol

出典と根拠

ORDレコード
ord-6a5276de0c8b4ae0904068fa150a32d3
出典データセット
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09150555B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート