Iodobenzene → HCID 70979993、化合物

反応式

[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=1[O:28][CH3:29])[C:8]1[CH:9]=[CH:10][C:11]2[NH:12][C:13](=[O:18])[NH:14][CH2:15][C:16]=2[N:17]=1)([CH3:4])([CH3:3])[CH3:2].I[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=1[O:28][CH3:29])[C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:13](=[O:18])[N:14]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:15][C:16]=2[N:17]=1)([CH3:4])([CH3:3])[CH3:2].[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=1[O:28][CH3:29])[C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:13](=[O:18])[NH:14][CH2:15][C:16]=2[N:17]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 11575Iodobenzene

HCID 70981319(2,4-Dimethoxy-benzyl)-(2-oxo-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester

生成物 2

HCID 70979993HCID 70979993、化合物

HCID 70980135(2,4-Dimethoxy-benzyl)-(2-oxo-1,3-diphenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester

実験手順

(2,4-Dimethoxy-benzyl)-(2-oxo-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester (Example 20, product from Step 4) (1.09 g, 2.6 mmol, 1.0 equiv) was treated by following methods similar to those described in Example 21, Step 1 except that iodobenzene was used instead of 1-chloro-4-iodo-benzene to afford 420 mg of (2,4-dimethoxy-benzyl)-(2-oxo-1,3-diphenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester (MS: [M+H]+=567) and 358 mg of (2,4-dimethoxy-benzyl)-(2-oxo-1-phenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester. MS: [M+H]+=491.

出典と根拠

ORDレコード: ord-e711e09591b64bb19e024b3298368602
出典データセット: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09155743B2

反応ノート

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