Hydrochloric Acid → HCID 118162198、化合物

HRID 1749534

反応式

HRID 1749534 の反応式
[ClH:1].[F:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][CH2:13][NH2:14])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.Cl.CS(C)=[O:18]>>[ClH:1].[NH2:14][CH2:13][CH2:12][CH:7]1[C:6]2[C:10](=[CH:11][C:3]([F:2])=[CH:4][CH:5]=2)[NH:9][C:8]1=[O:18]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 30850786-Fluoro-1H-indole-3-ethylamine monohydrochloride

生成物 1

HCID 118162198HCID 118162198、化合物収率 47%

反応条件

温度
50 °C

実験手順

To a solution of 2-(6-fluoro-1H-indol-3-yl)ethanamine hydrochloride (500 mg, 2.3 mmol) in DMSO (0.8 mL) was added hydrochloric acid (36%, 1.3 g, 12.8 mmol). The resulting reaction mixture was stirred at 50° C. in a sealed tube for 6 h. After cooling to room temperature, the reaction mixture was filtered. The resulting cake was stirred in EtOH (5 mL). The mixture was filtered and dried to give the desired product (250 mg, 1.28 mmol, 47% yield) as a yellow solid. MS (ESI) m/z 195.1 [M+H]+.

後処理

  1. customThe resulting reaction mixture
  2. temperatureAfter cooling to room temperature
  3. filtrationthe reaction mixture was filtered
  4. stirringThe resulting cake was stirred in EtOH (5 mL)
  5. filtrationThe mixture was filtered
  6. customdried

出典と根拠

ORDレコード
ord-02d7faa9def14b0a8852b78dc2eb5fce
出典データセット
uspto-grants-2015_10
特許番号
US09156798B2

関連ノート

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