Hydrochloric Acid → 3-(2-aminoethyl)-2,3-dihydro-1H-indol-2-one hydrochloride
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][NH2:12])=[CH:2]1.CS(C)=[O:15].[ClH:17]>>[ClH:17].[NH2:12][CH2:11][CH2:10][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:15]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 2-(1H-indol-3-yl)ethanamine (6.00 g, 37.50 mmol) in DMSO (8.0 mL, 112.50 mmol) was added concentrated hydrochloric acid (9.5 mL, 112.50 mmol) slowly. The resulting reaction mixture was stirred at 50° C. in a sealed tube for 16 h. After cooling to room temperature, the reaction mixture was filtered. The resulting cake was stirred in EtOH (15 mL). The mixture was filtered and dried to give the desired title compound as a brown solid (5.00 g, 23.64 mmol, 63% yield). MS (ESI) m/z 177.2 [M+H]+.
後処理
- customThe resulting reaction mixture
- temperatureAfter cooling to room temperature
- filtrationthe reaction mixture was filtered
- stirringThe resulting cake was stirred in EtOH (15 mL)
- filtrationThe mixture was filtered
- customdried
出典と根拠
- ORDレコード
- ord-24e71ac7b92141479d979681e2356368
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156798B2
反応ノート
読み込み中…