HCID 178520033、化合物 → HCID 178520032、化合物

HRID 1749865

反応式

HRID 1749865 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH2:11][OH:12]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=[O:12]

参加物

4

反応物 1

HCID 178520033HCID 178520033、化合物

生成物 1

HCID 178520032HCID 178520032、化合物収率 70.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of (5-fluoro-1H-indazol-3-yl)methanol (0.215 g, 1.29 mmol) in ethyl acetate (10 mL) was added with manganese dioxide (1.12 g, 12.9 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 5-fluoro-1H-indazole-3-carbaldehyde (0.150 g, 70%).

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)

出典と根拠

ORDレコード
ord-6d2bea766d1d4247a844bb381000f9b8
出典データセット
uspto-grants-2015_10
特許番号
US09156827B2

関連ノート

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