HCID 178520030、化合物 → 5-chloro-1H-indazole-3-carbaldehyde
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH2:11][OH:12]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=[O:12]参加物
4
実験手順
A solution of (5-chloro-1H-indazol-3-yl)methanol (0.208 g, 1.14 mmol) in ethyl acetate (10 mL) was added with manganese dioxide (0.991 g, 11.4 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 5-chloro-1H-indazole-3-carbaldehyde (0.106 g, 51%).
後処理
- filtrationThe reaction mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)
出典と根拠
- ORDレコード
- ord-d0874be4f7f54238a129321dc68e4fcb
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09156827B2
反応ノート
読み込み中…