Dichloromethane → 7-Fluoro-5-methyl-6-phenyl-2-(pyridin-3-yl)-1,3-benzoxazole-4-carbonitrile

HRID 17499

反応式

HRID 17499 の反応式
Cl.[CH2:2](Cl)[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.C(N(CC)CC)C.ClCCl.[NH2:20][C:21]1[C:26]([OH:27])=[C:25]([F:28])[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:23]([CH3:35])[C:22]=1[C:36]#[N:37]>C(OCC)(=O)C>[F:28][C:25]1[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:23]([CH3:35])[C:22]([C:36]#[N:37])=[C:21]2[C:26]=1[O:27][C:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)=[N:20]2

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 860974464-Amino-3-cyano-6-fluoro-5-hydroxy-2-methylbiphenyl

生成物 1

HCID 685843947-Fluoro-5-methyl-6-phenyl-2-(pyridin-3-yl)-1,3-benzoxazole-4-carbonitrile

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Nicotinyl chloride hydrochloride (192 mg, 1.08 mmol) and triethylamine (301 μl, 2.16 mmol) were added to a dichloromethane (9 ml) solution of 4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-41) (218 mg, 0.900 mmol), followed by stirring at room temperature for 2 hours. Ethyl acetate (100 ml) was added to the reaction liquid, followed by washing with water (50 ml) and saturated brine (50 ml).

後処理

  1. washby washing with water (50 ml) and saturated brine (50 ml)

出典と根拠

ORDレコード
ord-b06515a8803d431d872f27a069688415
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

関連ノート

読み込み中…