Water → 5-(Trifluoromethyl)-2-pyridinesulfonyl chloride

HRID 1750027ノート

反応式

HRID 1750027 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](S)=[N:7][CH:8]=1.[Cl:12][O-].[Na+].O.[OH:16][S:17]([OH:20])(=O)=O>>[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:17]([Cl:12])(=[O:20])=[O:16])=[N:7][CH:8]=1

参加物

5

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 23665760Sodium HypochloriteHCID 178506226HCID 178506226、化合物

生成物 1

HCID 117469095-(Trifluoromethyl)-2-pyridinesulfonyl chloride収率 79%

実験手順

0.8 g (4.47 mmol) of 5-trifluoromethyl-pyridine-2-thiol is placed at −8° C. in 16 mL of H2SO4. 16.96 mL (35.7 mmol) of a 13% sodium hypochlorite solution is poured gently such that the temperature of the reaction medium does not exceed 5° C. This mixture is then stirred for 45 min, taken up by water and then extracted using AcOEt. After drying followed by reduction to dryness of the organic phases, an oil is isolated (yield: 79%) and used as such for the next reactions.

後処理

  1. customdoes not exceed 5° C
  2. extractionextracted
  3. customAfter drying
  4. customan oil is isolated (yield: 79%)

出典と根拠

ORDレコード
ord-7de90a654fc241a386f0d5b3fb366b36
出典データセット
uspto-grants-2015_10
特許番号
US09156834B2

反応ノート

読み込み中…