ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → 2-(2-Ethylsulfanyl-4-trifluoromethylsulfanyl-phenyl)-5-trifluoromethylsulfanylbenzoxazole

HRID 1750064
ノート
印刷プレビュー

反応式

HRID 1750064 の反応式
[F:1][C:2]([F:15])([F:14])[S:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH:11]=[N:10][C:9]=2[CH:13]=1)=O.Br[C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]([F:27])([F:26])[F:25])=[CH:19][C:18]=1[S:28][CH2:29][CH3:30].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O.C([O-])(=O)C.[Cu+2].C([O-])(=O)C.O.C(OCC)(=O)C.C1(C)C=CC=CC=1>[CH2:29]([S:28][C:18]1[CH:19]=[C:20]([S:23][C:24]([F:27])([F:25])[F:26])[CH:21]=[CH:22][C:17]=1[C:11]1[O:12][C:8]2[CH:7]=[CH:6][C:5]([S:3][C:2]([F:15])([F:14])[F:1])=[CH:13][C:9]=2[N:10]=1)[CH3:30]
参加物実験手順後処理出典と根拠反応ノート

参加物

10

反応物 4

HCID 11430Potassium CarbonateHCID 11776TriphenylphosphineHCID 1180354975-((Trifluoromethyl)sulfinyl)benzo[d]oxazoleHCID 1180355631-Bromo-2-ethylsulfanyl-4-trifluoromethylsulfanylbenzene

生成物 1

HCID 1180353892-(2-Ethylsulfanyl-4-trifluoromethylsulfanyl-phenyl)-5-trifluoromethylsulfanylbenzoxazole収率 15.5%

試薬・触媒・溶媒 5

HCID 165397Cupric acetate monohydrate触媒HCID 167845palladium(II) acetate触媒HCID 962Water溶媒HCID 1140Toluene溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 0.10 g of 5-trifluoromethylsulfinylbenzoxazole, 0.15 g of 1-bromo-2-ethylsulfanyl-4-trifluoromethylsulfanylbenzene, 0.01 g of palladium(II) acetate, 0.01 g of triphenylphosphine, 0.02 g of copper(II) acetate monohydrate, 0.13 g of potassium carbonate and 3 ml of toluene was stirred under heating and refluxing for 2 hours. Ethyl acetate and water were added to the cooled reaction mixture, and the mixture was extracted with ethyl acetate and then dried with anhydrous sodium sulfate. The residue obtained by concentrating the mixture under reduced pressure was applied to a silica gel column chromatography to obtain 0.03 g of 2-(2-ethylsulfanyl-4-trifluoromethylsulfanyl-phenyl)-5-trifluoromethylsulfanylbenzoxazole (hereinafter, referred to as Compound 19).

後処理

  1. temperatureunder heating
  2. temperaturerefluxing for 2 hours
  3. extractionthe mixture was extracted with ethyl acetate
  4. dry with materialdried with anhydrous sodium sulfate
  5. customThe residue obtained
  6. concentrationby concentrating the mixture under reduced pressure

出典と根拠

ORDレコード
ord-17ceabe3a46947c0ab7d1dbbe3b97cd2
出典データセット
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09156838B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート