Hydrochloric Acid → (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride

HRID 1750184ノート

反応式

HRID 1750184 の反応式
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14](=[O:18])(=[O:17])[NH:15][CH3:16])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:16][NH:15][S:14]([CH2:13][C@@H:8]([NH2:7])[CH2:9][CH:10]([CH3:11])[CH3:12])(=[O:17])=[O:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86714402((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester

生成物 1

HCID 86714400(S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

105 mg of ((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester were dissolved in 2 ml of dioxane and reacted with 1.3 ml of 4M hydrochloric acid in dioxane at it for 16 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 60 mg (100%) of (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride were obtained.

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

出典と根拠

ORDレコード
ord-b74da5948bf1434dae962c804cfef3db
出典データセット
uspto-grants-2015_10
特許番号
US09156796B2

反応ノート

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