5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one → 6-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1750452ノート

反応式

HRID 1750452 の反応式
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22](O)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:25]1[C:34]2[CH2:33][CH2:32][NH:31][CH2:30][C:29]=2[CH:28]=[CH:27][C:26]1=[O:35]>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22]([N:31]3[CH2:32][CH2:33][C:34]4[NH:25][C:26](=[O:35])[CH:27]=[CH:28][C:29]=4[CH2:30]3)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

参加物

3

反応物 2

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-oneHCID 867212902-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid

生成物 1

HCID 712507616-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

実験手順

Using 2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid and 5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

後処理

  1. customby reaction and purification in the same manner as in the method

出典と根拠

ORDレコード
ord-564983da2cb248ba84f5fb347a8c730e
出典データセット
uspto-grants-2015_10
特許番号
US09156837B2

反応ノート

読み込み中…