Hydrochloric Acid → (1S,2S)-1-N-[3-Cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

HRID 1750568ノート

反応式

HRID 1750568 の反応式
[CH:1]1([C:4]2[C:5]([NH:14][C@H:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[NH:20]C(=O)OC(C)(C)C)=[N:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=2)[CH2:3][CH2:2]1.[ClH:28]>O1CCOCC1>[ClH:28].[CH:1]1([C:4]2[C:5]([NH:14][C@H:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[NH2:20])=[N:6][CH:7]=[C:8]([C:10]([F:12])([F:13])[F:11])[N:9]=2)[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 118308262tert-Butyl N-[(1S,2S)-2-{[3-cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate

生成物 1

HCID 118308108(1S,2S)-1-N-[3-Cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of tert-butyl N-[(1S,2S)-2-{[3-cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate (1.54 g, 3.99 mmol) in 1,4-dioxane (14 ml) was added HCl in 1,4-dioxane (4M, 10 ml, 40 mmol). The reaction was stirred at room temperature for 20 hours and was then concentrated in vacuo and azeotropically distilled with toluene to afford the title compound.

後処理

  1. concentrationwas then concentrated in vacuo
  2. distillationazeotropically distilled with toluene

出典と根拠

ORDレコード
ord-de352cbc89984acdbab37a740644e4fd
出典データセット
uspto-grants-2015_10
特許番号
US09156829B2

反応ノート

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