2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide → N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

HRID 17510ノート

反応式

HRID 17510 の反応式
C([O:8][CH2:9][C:10]([NH:12][C:13]1[C:18]([C:19]#[N:20])=[C:17]([CH3:21])[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([F:28])[C:14]=1[OH:29])=[O:11])C1C=CC=CC=1>[C].[Pd].C(O)C>[C:19]([C:18]1[C:13]([NH:12][C:10](=[O:11])[CH2:9][OH:8])=[C:14]([OH:29])[C:15]([F:28])=[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:17]=1[CH3:21])#[N:20]

参加物

4

反応物 1

HCID 866308382-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide

生成物 1

HCID 86630863N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

後処理

  1. customAfter the reaction
  2. customthe insoluble matter was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customto obtain the entitled compound
  5. customNot purified
  6. customthis was used in the next reaction as such

出典と根拠

ORDレコード
ord-648b7b07cd4b472093af3e33c292ca65
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

反応ノート

読み込み中…