Morpholine → HCID 58855409、化合物

反応式

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]([F:24])([C:15]([F:23])([F:22])[C:16]([F:21])([F:20])[CH:17]([F:19])[F:18])[CH2:9][O:10][CH2:11][CH:12]1[O:14][CH2:13]1>>[O:4]1[CH2:5][CH2:6][N:1]([CH2:13][CH:12]([OH:14])[CH2:11][O:10][CH2:9][C:8]([F:7])([F:24])[C:15]([F:22])([F:23])[C:16]([F:21])([F:20])[CH:17]([F:19])[F:18])[CH2:2][CH2:3]1

参加物

反応物 2

HCID 8083Morpholine

HCID 27758863-(1h,1h,5h-Octafluoropentyloxy)-1,2-epoxypropane

生成物 1

HCID 58855409HCID 58855409、化合物収率 89.1%

反応条件

温度: 80 °C

実験手順

To 8.7 g of morpholine was added dropwise 28.8 g of glycidyl 2,2,3,3,4,4,5,5-octafluoropentyl ether. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 33.4 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol (yield 89%).

後処理

customThe reaction mixture was directly purified by silica gel column chromatography

出典と根拠

ORDレコード: ord-f2d8bde5aac24984aa97e247b4bbb597
出典データセット: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09158191B2

反応ノート

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