Hydrochloric Acid → 7-Bromochromone

HRID 1751401ノート

反応式

HRID 1751401 の反応式
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:15])/[CH:10]=[CH:11]/N(C)C)=[C:5]([OH:16])[CH:4]=1>ClCCl>[Br:2][C:3]1[CH:4]=[C:5]2[C:6]([C:9](=[O:15])[CH:10]=[CH:11][O:16]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 11737295(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one

生成物 1

HCID 186867527-Bromochromone収率 100,000%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of concentrated hydrochloric acid (30 mL) was added to a solution of (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one (10.4 g, 38.5 mmol) in dichloromethane (250 mL). The mixture was heated at reflux for 30 minutes and cooled to room temperature. The aqueous phase was extracted with dichloromethane (20 mL). The combined organic phases were washed with saturated sodium bicarbonate (50 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to yield 7-bromo-4H-chromen-4-one (8.7 g, 38.5 mol, 100%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 30 minutes
  3. extractionThe aqueous phase was extracted with dichloromethane (20 mL)
  4. washThe combined organic phases were washed with saturated sodium bicarbonate (50 mL)
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-7a1acb49fd9f44058ade568147b52fcd
出典データセット
uspto-grants-2015_10
特許番号
US09156823B2

反応ノート

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