Pyridinium chloride → 8-bromo-6H-dibenzo[c,h]-chromen-2-ol
反応式
Cl.N1C=CC=CC=1.[Br:8][C:9]1[CH:10]=[CH:11][C:12]2[C:21]3[C:16](=[C:17]4[CH:25]=[CH:24][C:23]([O:26]C)=[CH:22][C:18]4=[CH:19][CH:20]=3)[O:15][CH2:14][C:13]=2[CH:28]=1>O>[Br:8][C:9]1[CH:10]=[CH:11][C:12]2[C:21]3[C:16](=[C:17]4[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][C:18]4=[CH:19][CH:20]=3)[O:15][CH2:14][C:13]=2[CH:28]=1参加物
4
反応条件
- 温度
- 190 °C
実験手順
Pyridine hydrochloride (4.4 g, 37.8 mmol) was heated to 190° C. 8-bromo-2-methoxy-6H-dibenzo[c,h]chromene (1.29 g, 3.8 mmol) was added and the reaction was stirred at 190° C. After four hours, the reaction was cooled to room temperature and diluted with water. A precipitate formed which was collected by filtration and purified by flash column chromatography to yield 8-bromo-6H-dibenzo[c,h]-chromen-2-ol (697 mg, 56%).