Tert-butyl 2,2,2-trichloroethanimidate → Tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

HRID 1751771ノート

反応式

HRID 1751771 の反応式
[C:1]([O:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Br:15])[CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].[C:16](OC(=N)C(Cl)(Cl)Cl)([CH3:19])([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:1]([O:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Br:15])[CH:10]=1)[C:6]([O:8][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:7])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 2734700Tert-butyl 2,2,2-trichloroethanimidateHCID 712121582-Acetoxy-2-(3-bromophenyl)acetic acid

生成物 1

HCID 71229801Tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of compound 2 (500 mg, 1.83 mmol) in toluene (2.5 mL) was added t-butyl-trichloroacetimidate (0.33 mL). The reaction was stirred at room temperature for 5 hours. The solid precipitate was filtered off and washed with toluene. The filtrate was concentrated in vacuo to provide compound 3 which was used in the next reaction without further purification.

後処理

  1. filtrationThe solid precipitate was filtered off
  2. washwashed with toluene
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-427ee3c634324aae8f0eeb5b7737308f
出典データセット
uspto-grants-2015_10
特許番号
US09161924B2

反応ノート

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