Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 1752214

反応式

HRID 1752214 の反応式
[Br:1]Br.[NH2:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1>CC(O)=O>[NH2:3][C:4]1[C:11]([Br:1])=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1

参加物

4

反応物 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

生成物 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile収率 49.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Br2 (0.52 mL, 0.01 mol) was added to a solution of 6-aminonicotinonitrile (1.1901 g, 0.01 mol) in AcOH (10 mL) at room temperature. The mixture was stirred at room temperature for 2 h. Then the mixture was concentrated and the residue was purified by flash column chromatography to give the title product (980.0 mg, 49%).

後処理

  1. concentrationThen the mixture was concentrated
  2. customthe residue was purified by flash column chromatography

出典と根拠

ORDレコード
ord-3c3f73d384034bff9d09d4b9052641f3
出典データセット
uspto-grants-2015_10
特許番号
US09162980B2

関連ノート

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