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Triphosgene → 1-Hydroxy-4-adamantyl chloroformate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphosgene | HCID 94429 | — |
| 反応物 | Adamantane-1,4-diol | HCID 4252005 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Hydroxy-4-adamantyl chloroformate | HCID 58171499 | — |
反応手順
A solution of 1,4-adamantanediol (210 mg, 1.25 mmol) in dry pyridine (3 mL) and dry CH2Cl2 (6 mL) was cooled in an ice bath and a solution of triphosgene (122 mg, 0.41 mmol) in dry Ch2Cl2 (3 mL) was added dropwise over 5 min. The mixture was stirred in the ice bath for 3 h to afford a 0.1 M solution of 1-hydroxy-4-adamantyl chloroformate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09163012B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-08dce3b9c49c4bf7b2f13c4f1e925941 |
| 出典メモ | uspto-grants-2015_10 |