Hydrochloric Acid → HCID 89767058、化合物

HRID 1752513ノート

反応式

HRID 1752513 の反応式
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[C:13]([NH:15][CH2:16][CH:17]1[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]1)=[O:14]>CCOCC.CO>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[C:13]([NH:15][CH2:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:14]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 89768864Tert-butyl 4-({[(5-methoxy-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

生成物 1

HCID 89767058HCID 89767058、化合物収率 89%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

2 M HCl in Et2O (1.8 L) was added to a solution of compound 7a (92.8 g, 0.24 moles) in MeOH (500 mL). The mixture was stirred for 3 hours at room temperature then the resulting solid was filtered and dried to give 5-methoxy-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamide hydrochloride 7b (61.1 g, 89% yield).

後処理

  1. filtrationthe resulting solid was filtered
  2. customdried

出典と根拠

ORDレコード
ord-c040e71adf424151a84dc880be1bf8b7
出典データセット
uspto-grants-2015_10
特許番号
US09163013B2

反応ノート

読み込み中…