Hydrochloric Acid → HCID 89767022、化合物

HRID 1752519ノート

反応式

HRID 1752519 の反応式
[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)=[O:13]>CCOCC.CO>[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1)=[O:13]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 89767452Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

生成物 1

HCID 89767022HCID 89767022、化合物収率 76%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

2M HCl in Et2O (1.8 L) was added to a solution of compound tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 11a (0.24 moles) in MeOH (500 mL). The mixture was stirred for 3 hours at room temperature then the resulting solid was filtered and dried to give 5-Bromo-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamide hydrochloride 11 b (76% yield).

後処理

  1. filtrationthe resulting solid was filtered
  2. customdried

出典と根拠

ORDレコード
ord-a61cb7650da5463db61b05f77772520b
出典データセット
uspto-grants-2015_10
特許番号
US09163013B2

反応ノート

読み込み中…