5-Methyl-7-(4-pyridyl)-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione → 5-Methyl-7-pyridin-4-yl-2-(2-quinolin-2-yl-ethyl)-1,2-dihydro-5H-pyrrolo[3,4-c]pyridine-3,6-dione

HRID 1752611ノート

反応式

HRID 1752611 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)=[C:5]2[C:15](=O)[N:16]([CH2:19][CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)[C:17](=[O:18])[C:4]2=[CH:3]1>C(O)(=O)C.[Zn]>[CH3:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)=[C:5]2[CH2:15][N:16]([CH2:19][CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)[C:17](=[O:18])[C:4]2=[CH:3]1

参加物

4

反応物 1

HCID 862956345-Methyl-7-(4-pyridyl)-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione

生成物 1

HCID 862956385-Methyl-7-pyridin-4-yl-2-(2-quinolin-2-yl-ethyl)-1,2-dihydro-5H-pyrrolo[3,4-c]pyridine-3,6-dione収率 40%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

反応条件

温度
110 °C

実験手順

A mixture of 5-methyl-7-(4-pyridyl)-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione (60 mg, 0.15 mmol, see Example 4) and zinc power (28 mg, 0.4 mmol) in acetic acid (3 ml) was stirred at 110° C. for 3 hours. The solution was concentrated and purified by column chromatography on silica gel (EA:MeOH=5:1) to give the title compound as a white solid (23 mg, 40%).

後処理

  1. concentrationThe solution was concentrated
  2. custompurified by column chromatography on silica gel (EA:MeOH=5:1)

出典と根拠

ORDレコード
ord-4cdad4c916454bc1939566d51c9b10a0
出典データセット
uspto-grants-2015_10
特許番号
US09163019B2

反応ノート

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