2-(4-Chlorophenoxy)ethylamine → N-[2-(4-chlorophenoxy)ethyl]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine

HRID 1752803ノート

反応式

HRID 1752803 の反応式
CS([C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([CH3:13])[N:7]2[N:6]=1)(=O)=O.[Cl:16][C:17]1[CH:26]=[CH:25][C:20]([O:21][CH2:22][CH2:23][NH2:24])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:26]=[CH:25][C:20]([O:21][CH2:22][CH2:23][NH:24][C:5]2[N:15]=[C:8]3[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([CH3:13])[N:7]3[N:6]=2)=[CH:19][CH:18]=1

参加物

3

反応物 2

HCID 27941912-(4-Chlorophenoxy)ethylamineHCID 713561592-(Methanesulfonyl)-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine

生成物 1

HCID 86719321N-[2-(4-chlorophenoxy)ethyl]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine収率 26%

実験手順

The title compound was prepared according to the experimentals described for Example 18 above from 2-methanesulfonyl-5,7-dimethyl-[1,2,4]-triazolo[1,5-a]pyrimidine and 2-(4-chlorophenoxy)ethylamine in 26% yield; EM (calc.): 317.1; MS (ESI) m/e: 318.2 (M+H)+. 1H NMR (DMSO-d6, 400 MHz) δ ppm: 7.31 (dt, 2H), 7.03 (d, 1H), 6.98 (dt, 2H), 6.85 (s, 1H), 4.13 (t, 2H), 3.60 (q, 2H), 2.57 (s, 3H), 2.45 (s, 3H).

出典と根拠

ORDレコード
ord-b36620f925ab43bb8a380c1566f4847e
出典データセット
uspto-grants-2015_10
特許番号
US09163027B2

反応ノート

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