化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorophenol → 2-[3-(4-Fluorophenoxy)propyl]-5,7-bis(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | 3,5-Heptanedione, 2,6-dimethyl- | HCID 87597 | — |
| 反応物 | HCID 178508402 | HCID 178508402 | — |
| 反応物 | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
| 生成物 | 2-[3-(4-Fluorophenoxy)propyl]-5,7-bis(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine | HCID 76684793 | 61% |
| 生成物 | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
反応手順
The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 2,6-dimethyl-3,5-heptanedione in 61% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. EM (calc.): 356.2; MS (ESI) m/e: 357.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09163027B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-0e8312fa9e09458bb6dc6af7b540ba54 |
| 出典メモ | uspto-grants-2015_10 |