5-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine → HCID 67075374、化合物

反応式

C[Sn](C)(C)[C:3]1([F:18])[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][C@H:12]([CH2:14][OH:15])[O:11][C:10]2=[O:16])=[CH:5][CH:4]1[F:17].[CH3:21][C:22]1[O:23][C:24]([C:27]2[CH:32]=[CH:31][C:30](Br)=[CH:29][N:28]=2)=[N:25][N:26]=1>>[CH3:21][C:22]1[O:23][C:24]([C:27]2[CH:32]=[CH:31][C:30]([C:3]3([F:18])[CH:8]=[CH:7][C:6]([N:9]4[CH2:13][C@H:12]([CH2:14][OH:15])[O:11][C:10]4=[O:16])=[CH:5][CH:4]3[F:17])=[CH:29][N:28]=2)=[N:25][N:26]=1

参加物

反応物 2

HCID 234386435-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine

HCID 68820223HCID 68820223、化合物

生成物 1

HCID 67075374HCID 67075374、化合物

実験手順

The same procedure as in Example 1 was conducted by using (R)-3-(4-trimethylstannyl-3,4-difluorophenyl)-2-oxo-5-oxazolidinylmethanol and 2-(2-methyl-[1,3,4]oxadiazol-5-yl)-5-bromopyridine as a starting material, to prepare the title compound.

出典と根拠

ORDレコード: ord-81edb186239742ed8ba63a2656407d84
出典データセット: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09163043B2

反応ノート

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