Ethyl orthoformate → Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
反応式
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:13]([O:15][CH:16](OCC)OCC)[CH3:14]>C(OC(=O)C)(=O)C>[CH2:13]([O:15]/[CH:16]=[C:4](/[C:3](=[O:10])[C:2]([F:11])([F:12])[F:1])\[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:14]参加物
4
実験手順
To a solution of ethyl 4,4,4-trifluoro-3-oxobutanoate (20 g, 108.63 mmol) in acetic anhydride (39 mL) was added triethylorthoformate (54.2 mL, 325.89 mmol) and the reaction heated to reflux for 18 hours. The reaction was cooled, concentrated in vacuo and used directly in the next step.
後処理
- temperaturethe reaction heated
- temperatureto reflux for 18 hours
- temperatureThe reaction was cooled
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-c4d1ba12b2db4c698f4e8d65ad4744ba
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09163021B2
反応ノート
読み込み中…