4-Pyrrolidinopyridine → 4-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

HRID 1753805

反応式

HRID 1753805 の反応式
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[N:10]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

参加物

4

反応物 2

HCID 755674-PyrrolidinopyridineHCID 2472224-Chloro-6-hydrazinylpyrimidine

生成物 1

HCID 596037004-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2.0 g (13.8 mmol) of the compound from Example 7A and 4.3 g (27.7 mmol) 4-pyrrolidin-1-ylpyridine is stirred in 20 ml water at 100° C. for 16 h. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

後処理

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. washwashed first with ethanol
  4. dry with materialwith diethyl ether and dried in vacuo

出典と根拠

ORDレコード
ord-a5d3caab4cc24a7aae1f6c16ab355b33
出典データセット
uspto-grants-2015_10
特許番号
US09168249B2

関連ノート

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