Ethanol → Ethyl 4-methyl-1H-1,2,3-triazole-1-acetate
反応式
[CH3:1][C:2]1[N:3]=[N:4][N:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.[CH2:11](O)[CH3:12]>S(=O)(=O)(O)O>[CH2:11]([O:9][C:8](=[O:10])[CH2:7][N:5]1[CH:6]=[C:2]([CH3:1])[N:3]=[N:4]1)[CH3:12]参加物
4
実験手順
2.0 g (14.2 mmol) (4-methyl-1H-1,2,3-triazol-1-yl)acetic acid are dissolved in 30 ml ethanol and 10 drops of conc. sulfuric acid are added. The reaction mixture is stirred at RT for 16 h. For working up, the mixture is concentrated in vacuo, ethyl acetate is added to the residue and the suspension is washed with half-concentrated sodium bicarbonate solution. The organic phase is dried over magnesium sulfate, the solvent is removed completely on a rotary evaporator and the solid is dried in vacuo.
後処理
- concentrationthe mixture is concentrated in vacuo, ethyl acetate
- additionis added to the residue
- washthe suspension is washed with half-concentrated sodium bicarbonate solution
- dry with materialThe organic phase is dried over magnesium sulfate
- customthe solvent is removed completely on a rotary evaporator
- customthe solid is dried in vacuo
出典と根拠
- ORDレコード
- ord-894d50257fb54a6194de117c9d15674e
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09168249B2
反応ノート
読み込み中…