Ammonia → 3-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

HRID 1753977ノート

反応式

HRID 1753977 の反応式
[Br:1][C:2]1[CH2:6][CH:5]([C:7]([O:9]CC)=O)[O:4][N:3]=1.[NH3:12]>CO>[Br:1][C:2]1[CH2:6][CH:5]([C:7]([NH2:12])=[O:9])[O:4][N:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 66696825Ethyl 3-bromo-4,5-dihydro-1,2-oxazole-5-carboxylate

生成物 1

HCID 441183083-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl 3-bromo-4,5-dihydroisoxazole-5-carboxylate (6.2 g, 28 mmol) and a solution of 2 M ammonia in MeOH (56 mL) was stirred at room temperature for 1 to 2 hours. Volatile materials were removed in vacuo to give the crude title compound as a white solid.

後処理

  1. customVolatile materials were removed in vacuo

出典と根拠

ORDレコード
ord-d011d876bc284934b51899a00d1ca052
出典データセット
uspto-grants-2015_10
特許番号
US09168248B2

反応ノート

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