Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene

HRID 1754059

反応式

HRID 1754059 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropane

生成物 1

HCID 156257521-Bromo-4-(cyclopropylmethoxy)benzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried over MgSO4 and the solvent is removed in vacuo.

後処理

  1. extractionextracted with DCM
  2. dry with materialThe organic layer is dried over MgSO4
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-c5898888703d450b96cc0836bd4c9444
出典データセット
uspto-grants-2015_10
特許番号
US09169205B2

関連ノート

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