Formic Acid → HCID 86724386、化合物

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH:14](O)=[O:15]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([NH:13][CH:14]=[O:15])[CH:10]=[N:9]2)=[CH:6][CH:7]=1

参加物

反応物 2

HCID 284Formic Acid

HCID 435317151-(4-fluorophenyl)-1H-pyrazol-4-amine

生成物 1

HCID 86724386HCID 86724386、化合物収率 71%

実験手順

A solution of 1-(4-fluorophenyl)pyrazol-4-amine (0.59 g, 3.3 mmol) in formic acid (15 mL) was heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature, concentrated in vacuo, and purified by flash chromatography (SiO2, 0-100% EtOAc/CH2Cl2 gradient elution) to give N-[1-(4-fluorophenyl)pyrazol-4-yl]formamide (0.490 g, 71%).

後処理

concentrationconcentrated in vacuo
custompurified by flash chromatography (SiO2, 0-100% EtOAc/CH2Cl2 gradient elution)

出典と根拠

ORDレコード: ord-766cc96f4dad47c7b519b10170916a69
出典データセット: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09169248B2

反応ノート

読み込み中…

参加物