Phosphorus tribromide → 5-(Bromomethyl)-1-methyl-1H-benzotriazole
反応式
P(Br)(Br)[Br:2].[CH3:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([CH2:15]O)=[CH:14][C:9]=2[N:8]=[N:7]1>C(OCC)C.O>[Br:2][CH2:15][C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH3:5])[N:7]=[N:8][C:9]=2[CH:14]=1参加物
5
実験手順
Phosphorus tribromide (0.230 ml, 2.45 mmol) is added to a stirred solution of (1-methyl-1H-1,2,3-benzotriazole-5-yl)methanol (0.4 g, 2.45 mmol) in diethyl ether (25 ml) under an inert atmosphere of Argon. After stirring overnight at room temperature, the reaction mixture is diluted with water (5 ml) and stirred vigorously for 10 minutes. The organic portion is separated, washed with water (2×5 ml), brine (2×5 ml) and concentrated in vacuo to yield the titled product which is used crude in the next step. (MH+226).
後処理
- stirringstirred vigorously for 10 minutes
- customThe organic portion is separated
- washwashed with water (2×5 ml), brine (2×5 ml)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-be6a705bdd954863b4fff2d7bd9691a7
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09169251B2
反応ノート
読み込み中…