Formic Acid → 5-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazole

HRID 1754967ノート

反応式

HRID 1754967 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[CH:14](O)=O>>[Br:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]2[NH:12][CH:14]=[N:13][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 105389214-Bromo-5-(trifluoromethyl)benzene-1,2-diamine

生成物 1

HCID 594745905-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazole

反応条件

温度
120 °C

実験手順

4-Bromo-5-trifluoromethyl-benzene-1,2-diamine (200 mg, 0.785 mmol) was dissolved in formic acid (3 ml), and the mixture was stirred at 120° C. for six hours. The reaction solution was concentrated, and water was added to the resulting residue, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5-bromo-6-trifluoromethyl-1H-benzimidazole (201 mg) as a crude compound.

後処理

  1. concentrationThe reaction solution was concentrated
  2. additionwater was added to the resulting residue
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layer was washed with water and saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-52cb3350046b47b7bd05642a780922b7
出典データセット
uspto-grants-2015_10
特許番号
US09169254B2

反応ノート

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