2-Methylpyrrolidine → 6-chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

HRID 1755292ノート

反応式

HRID 1755292 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14](F)[N:13]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[CH3:19][CH:20]1[CH2:24][CH2:23][CH2:22][NH:21]1>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N:21]3[CH2:22][CH2:23][CH2:24][CH:20]3[CH3:19])[N:13]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1

参加物

4

反応物 2

HCID 130032-MethylpyrrolidineHCID 866826956-chloro-N-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

生成物 1

HCID 715343846-chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine収率 63.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
205 °C

実験手順

A suspension of 6-chloro-N-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (132 mg, 0.5 mmol) and 2-methylpyrrolidine (64 mg, 0.75 mmol) in water (0.3 mL) was heated to 205° C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, CH2Cl2:MeOH=200:1) to give 6-chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (105 mg, 63.8%) as a yellow solid. LC-MS: [M+H]+, 329.1, tR=2.019 min.

後処理

  1. customThe reaction mixture was purified by chromatography (silica gel, 200-300 mesh, CH2Cl2:MeOH=200:1)

出典と根拠

ORDレコード
ord-082ba07690bc4ce3ba90592e421a9d58
出典データセット
uspto-grants-2015_10
特許番号
US09169259B2

反応ノート

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