Hydrochloric Acid → (S)-2-Amino-N-(3-(5-formylthiazol-2-ylamino)propyl)propanamide

HRID 1755466ノート

反応式

HRID 1755466 の反応式
[CH:1]([C:3]1[S:7][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:24])[C@@H:14]([NH:16]C(=O)OC(C)(C)C)[CH3:15])=[N:5][CH:4]=1)=[O:2].Cl.C(OCC)C>C(Cl)Cl>[NH2:16][C@@H:14]([CH3:15])[C:13]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]1[S:7][C:3]([CH:1]=[O:2])=[CH:4][N:5]=1)=[O:24]

参加物

5

反応物 3

HCID 313Hydrochloric Acid2 回HCID 3283Diethyl EtherHCID 86700112(S)-tert-Butyl 1-(3-(5-formylthiazol-2-ylamino)propylamino)-1-oxopropan-2-ylcarbamate

生成物 1

HCID 86700111(S)-2-Amino-N-(3-(5-formylthiazol-2-ylamino)propyl)propanamide収率 137.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Following the procedure as described in Example 68, except using material from Example 69 (265 mg, 0.743 mmol), CH2Cl2 (50 mL), HCl, 11.0M in diethyl ether (5 mL, 5.00 mmol) and stirring at room temp for 2.5 days, 262 mg (quantitative yield) of the title compound is obtained as a pale yellow solid, as a bis HCl salt by weight. LC/MS (Condition A): ret. T=0.93 min, (M+H)+ 257.14.

出典と根拠

ORDレコード
ord-691d65edd76342adb9ba7fca985f8d8c
出典データセット
uspto-grants-2015_10
特許番号
US09169295B2

反応ノート

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