Methylparaben → HCID 19917654、化合物
反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:13]([CH2:17][CH:18]=[CH2:19])[CH2:14][CH:15]=[CH2:16].[OH:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:16]=[CH:15][CH2:14][CH:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][O:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:29][CH:30]=1)[CH2:17][CH:18]=[CH2:19]参加物
5
実験手順
15 g of the compound (4), 8.3 g of methyl 4-hydroxybenzoate and 23 g of potassium carbonate were dissolved in 100 ml of 2-butanone, and reflux was carried out for 11 hours in an atmosphere of argon. After the solid matter generated was filtered off, the solvent was evaporated, and the residue was purified by a chromatography using a column filled with alumina and silica gel, to obtain 14 g of the compound (5). (Yield: 77%)