HCID 18657908、化合物 → HCID 131718807、化合物
反応式
[CH2:1]1[C@@H:5]2[CH2:6][C:7](=[O:8])[N:4]2[C:3]([C:9]([O-:11])=[O:10])=[CH:2]1.[SH:12][C@@H:13]1[CH2:17][N:16]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)=[O:19])[C@H:15]([CH:31]2[N:34]([CH3:35])[C:33](=[O:36])[CH2:32]2)[CH2:14]1>>[OH:36][C@@H:33]([C@H:6]1[C:7](=[O:8])[N:4]2[C:3]([C:9]([O:11][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=3)=[O:10])=[C:2]([S:12][C@@H:13]3[CH2:17][N:16]([C:18]([O:20][CH2:21][C:22]4[CH:23]=[CH:24][C:25]([N+:28]([O-:30])=[O:29])=[CH:26][CH:27]=4)=[O:19])[C@H:15]([CH:31]4[N:34]([CH3:35])[C:33](=[O:36])[CH2:32]4)[CH2:14]3)[CH2:1][C@H:5]12)[CH3:32]参加物
3
実験手順
The same procedure as in Example 1-1 was carried out by using p-nitrobenzyl (5R,6S)-2-diphenoxyphosphoryloxy-6-8 (R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate (235 mg, 0.40 mmol) and (2S,4S)-4-mercapto-2-(N-methyl-2-azetidinon-4-yl)-N-(p-nitrobenzyloxycarbonyl)pyrrolidine (149 mg, 0.41 mmol, compound of Reference Example 7) to obtain p-nitrobenzyl (5R,6S)-6-[(R)-1-hydroxyethyl]-2-[(2S,4S)-2-(N-methyl-2-azetidinon-4-yl)-N-(p-nitrobenzyloxycarbonyl)pyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylate (265 mg, yield: 94.5%).
出典と根拠
- ORDレコード
- ord-3a82097e0eb54521a860b0146f1764b4
- 出典データセット
- uspto-grants-1995_08