Thiocyanic Acid → 5-Hydroxymethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione

反応式

[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([NH2:13])[CH2:7]2.[N:14]#[C:15][SH:16].[OH:17][CH:18](O)[C:19](=O)[CH3:20]>>[OH:17][CH2:18][C:19]1[N:13]([CH:6]2[CH2:5][CH2:4][C:3]3[C:8](=[CH:9][C:10]([F:12])=[CH:11][C:2]=3[F:1])[CH2:7]2)[C:15](=[S:16])[NH:14][CH:20]=1

参加物

反応物 3

HCID 781Thiocyanic Acid

HCID 131809821,1-Dihydroxypropan-2-one

HCID 196994235,7-Difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamine

生成物 1

HCID 196993025-Hydroxymethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione

実験手順

reacting 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamine with thiocyanic acid and dihydroxyacetone to give 5-hydroxymethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione and

出典と根拠

ORDレコード: ord-15cf4d9f9fb3474198861d4893672bb0
出典データセット: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05438150

反応ノート

読み込み中…