Methylhydrazine → HCID 178514652、化合物

HRID 1755835ノート

反応式

HRID 1755835 の反応式
[OH:1][C:2]1[C:3](=[O:21])[N:4]=[C:5]([CH2:8][O:9][N:10]2C(=O)C3=CC=CC=C3C2=O)[NH:6][CH:7]=1.CNN>CN(C)C=O>[NH2:10][O:9][CH2:8][C:5]1[NH:6][CH:7]=[C:2]([OH:1])[C:3](=[O:21])[N:4]=1

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 1785150275-Hydroxy-2-[(phthalimidooxy)methyl]-4(1H)-pyrimidinone

生成物 1

HCID 178514652HCID 178514652、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
10 °C

実験手順

5-Hydroxy-2-[(phthalimidooxy)methyl]-4(1H)-pyrimidinone (0.875 g) (3 mmol) is suspended in 7 ml of dimethylformamide. 136 mg (3 mmol) of methylhydrazine are added thereto at 10° C. and the mixture is stirred at room temperature for 1 hour. The solution is washed four times with 50 ml of n-pentane, the solid residue is taken up in ether, the product is filtered off and crystallized from ethanol. There is obtained 2-(aminooxy)methyl-5-hydroxy-4(1H)-pyrimidinone of m.p. 163° C. (dec.) as white crystals.

後処理

  1. washThe solution is washed four times with 50 ml of n-pentane
  2. filtrationthe product is filtered off
  3. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-59af5be550ac4d548ee720e364dcebcb
出典データセット
uspto-grants-1995_08
特許番号
US05438052

反応ノート

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