Hydrochloric Acid → HCID 178432397、化合物

HRID 1755883ノート

反応式

HRID 1755883 の反応式
[SH:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=[C:4]([C:12]([O:14]C)=O)[CH:3]=1.[NH2:16][OH:17].Cl>CO>[OH:17][NH:16][C:12]([C:4]1[CH:3]=[C:2]([SH:1])[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=1)=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 178498634HCID 178498634、化合物

生成物 1

HCID 178432397HCID 178432397、化合物収率 107.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 7-mercapto-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxylate (500 mg) (2.23 mmol) are suspended in 100 ml of absolute methanol. 2.95 mg (8.9 mmol) of hydroxylamine are added within 4 days while stirring. The reaction mixture is acidified (pH 6) with 3N aqueous hydrochloric acid. The product is filtered off under suction and washed in succession with water, methanol and diethyl ether. There are obtained 540 mg of N-hydroxy-7-mercapto-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxamide as yellow crystals of melting point 178°-179° C.

後処理

  1. filtrationThe product is filtered off under suction
  2. washwashed in succession with water, methanol and diethyl ether

出典と根拠

ORDレコード
ord-86b72fd49362429bb0d7ecf901dbddb4
出典データセット
uspto-grants-1995_08
特許番号
US05438052

反応ノート

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