Hydrochloric Acid → HCID 178523964、化合物
反応式
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([SH:9])[N:6]2[N:10]=[C:11]([C:13]([O:15]C)=O)[N:12]=[C:5]2[N:4]=1.[NH2:17][OH:18].Cl>CO>[SH:9][C:7]1[N:6]2[N:10]=[C:11]([C:13]([NH:17][OH:18])=[O:15])[N:12]=[C:5]2[N:4]=[C:3]([CH2:2][OH:1])[CH:8]=1参加物
5
実験手順
Methyl 5-(hydroxymethyl)-7-mercapto-s-triazolo[1,5-a]pyrimidine-2-carboxylate (100 mg) (0.416 mmol) are dissolved in about 5 ml of methanol. 275 mg (8.3 mmol) of hydroxylamine are added thereto at room temperature while stirring within 48 hours. The reaction mixture is made acid (pH 5.5) with 3N aqueous hydrochloric acid. The product is filtered off under suction and crystallized from methanol. There are obtained 60 mg of 7-mercapto-N-hydroxy-5-(hydroxymethyl)-s-triazolo[1,5-a]pyrimidine-2-carboxamide as beige crystals of melting point 238°-239° C. (dec.).
後処理
- filtrationThe product is filtered off under suction
- customcrystallized from methanol
出典と根拠
- ORDレコード
- ord-c3eb16531ddf4e84b387499536ffbc23
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05438052
反応ノート
読み込み中…