Acetone → HCID 19917093、化合物

反応式

[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[CH:9]=[O:10])=[CH:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:20][C:21]([CH3:23])=[O:22]>>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH:9]([OH:10])[CH2:20][C:21](=[O:22])[CH3:23])[CH:11]=[CH:12][CH:13]=2)=[CH:2]1

参加物

反応物 3

HCID 180Acetone

HCID 11430Potassium Carbonate

HCID 45475263-(Thiophen-3-yl)benzaldehyde

生成物 1

HCID 19917093HCID 19917093、化合物

実験手順

300 mg of 3-(3-thienyl)benzaldehyde was dissolved in 3 ml of acetone, and 441 mg of potassium carbonate was added. The mixture was sirred overnight at room temperature, and then the solvent was evaporated. The residue was worked up in a customary manner, and purified by medium-pressure liquid chromatography [hexane/ethyl acetate =3/1] to give 1-[3-(3-thienyl)-phenyl]-3-oxo-1-butanol as a colorless oil.