Acetic Acid → Methyl 4-(6-amino-3-benzyloxyindazol-1-ylmethyl)-3-methoxybenzoate

HRID 1756411ノート

反応式

HRID 1756411 の反応式
[CH2:1]([O:8][C:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-])=O)=[CH:15][CH:16]=2)[N:11]([CH2:21][C:22]2[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=2[O:32][CH3:33])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=O)C>CCOCC.[Zn]>[NH2:18][C:14]1[CH:13]=[C:12]2[C:17]([C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[N:10][N:11]2[CH2:21][C:22]2[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=2[O:32][CH3:33])=[CH:16][CH:15]=1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 23365833Methyl 4-(3-benzyloxy-6-nitroindazol-1-ylmethyl)-3-methoxybenzoate

生成物 1

HCID 23365892Methyl 4-(6-amino-3-benzyloxyindazol-1-ylmethyl)-3-methoxybenzoate収率 85%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 3283Diethyl Ether溶媒

実験手順

Zinc dust (0.065 g.) was added to a stirred mixture of methyl 4-(3-benzyloxy-6-nitroindazol-1-ylmethyl)-3-methoxybenzoate (CC) (0.043 g.) and acetic acid (0.9 ml.). The mixture was stirred for 2 hours, diluted with ether, and filtered. The filtrate was washed with water, brine, dried (MgSO4), and evaporated to give methyl 4-(6-amino-3-benzyloxyindazol-1-ylmethyl)-3-methoxybenzoate (DD) (0.034 g., 85%) as a brown oil, and was used without further purification as described below.

後処理

  1. filtrationfiltered
  2. washThe filtrate was washed with water, brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-88b3172e84ef4c529e1b1003b94ae117
出典データセット
uspto-grants-1995_08
特許番号
US05440035

反応ノート

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